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Cats and mice are usually natural enemies. Even though cats like to chase and catch mice, having a cat doesn’t guarantee a pest-free home. You may have heard that getting a cat is a solution to a mouse problem. But will the smell of a cat keep mice from entering your home? If you bring a cat into your home and the mice smell them, will they leave?
The answer depends on various factors, including the cat’s personality. Let’s take a look at the reasons that mice smelling a cat won’t automatically make them leave your property.
Why Do Cats Catch Mice?
Cats are natural hunters even though they’ve been domesticated for thousands of years. They have not lost the instinct to hunt and catch prey. This doesn’t mean that every cat feels the same way, though.
When indoor cats are well-fed and happy, they may not always care about a mouse running throughout the house. If the cat is not as active or has physical limitations, they may not be able to run after mice even if they want to. Some cats are afraid of mice and don’t want to go near them.
All of this means that getting a cat is not a guarantee that your mice will be eliminated.

Can Mice Smell Cats?
Mice can smell cats even if they don’t know what a cat is. This is a survival tactic for mice that are instinctually aware, just by picking up a scent, that danger is near.
Like cats, mice have a vomeronasal organ that enables them to detect cat urine, saliva, and dander containing pheromones. The Scripps Research Institute conducted a study to see if mice that have never been exposed to any other species in their lives could detect the smell of cats and other predators.
Cotton balls soaked with cat saliva and urine were placed in the cages with the mice. The study determined that mice with active and normally functioning vomeronasal organs reacted with fear and cowered in the corner, trying to hide from a perceived threat.
Even though these mice have never been in the presence of a predator, they instinctively reacted with fear and self-preservation behavior at the scent of one.
Why Won’t the Mice Leave?
If mice react with terror at the scent of a cat, why don’t they leave the house if a cat is in it? The answer can vary, but the shortest and most direct answer is that mice can fit into places that cats cannot. You may not see mice in the same part of your home that your cat frequents. But mice are resourceful and can find other areas to live in safely.
If you have a mouse in your kitchen and your cat is usually in the living room, the mouse doesn’t detect as much danger and can find small places in which to curl up and hide. Even though the cat may enter the room, the mouse feels secure enough in their established domain to not be pushed out of the home. If the mouse lives in a hole in the wall or a cabinet, they will know that the cat can’t reach them in these places.

My Cat Always Catches Mice, So Why Do I Still Have Them?
Cats may like to catch mice, but they’re not always an effective source of mouse control. Here are two reasons that relying on your cat to catch mice will not always work to eliminate the problem.
- Mice may smell the cat, but they won’t always flee the property. They will find places to go that only they can access and continue to live and breed there. If your cat can’t access the nests, they can’t combat the issue. Catching one or two mice at a time won’t get rid of a mouse infestation, especially since mice can breed so quickly. A female mouse is only pregnant for 19–21 days. She can produce 32–56 babies each year. If you have multiple female mice reproducing in your home, there’s no way that even the best cat mouser can keep up.
- Cats can’t prevent mice from coming into the home. It is important to seal all gaps where mice can slip in. Keeping a tidy home with food properly stored will discourage mice from entering. Even if your cat catches one or two mice, two more could enter the house the next day. Mouse-proofing your home is the best way to keep unwanted infestations out.
Are Some Mice Just Not Afraid Of Cats?
You’ve probably seen images or videos of cats and mice seemingly enjoying each others’ company; the antithesis of a classic predator/prey dynamic. Just as some wild animals can become tame, some cats and mice, despite being natural ‘enemies,’ may learn to live together without conflict, even seeming to form a bond. Although this unusual relationship can develop, it should not be taken for granted, and we never recommend leaving cats unsupervised with pets of the tiny variety.
There are also cases where mice infected with the brain parasite Toxoplasma gondii will lose their instinctive fear of predators, including cats. This is the result of the parasite affecting part of the brain called the amygdala, which is responsible for converting fear into memory. Cats can also be infected with Toxoplasma, but it is usually only a transient infection, and most cats will not show any clinical signs.
Conclusion
Mice can smell cats, but it doesn’t mean they’ll leave your house once they do. Mice can find other areas to live and breed that your cat doesn’t have access to.
Cats can’t handle a mouse infestation on their own. If they catch one or two mice in your house, it won’t necessarily make the other mice leave. They can breed too quickly for a cat to keep up.
If the mice aren’t leaving your home even if you have a cat, you should investigate other ways to remove them and keep them from returning. Filling gaps and entry points, removing clutter, and keeping food properly stored will go a long way toward preventing another infestation.
Featured Image Credit: Milada Vigerova, Pixabay