8 Best Cat Urine, Odor & Stain Removers in 2025 – Reviews & Top Picks

If you have a cat, you know that they can go outside the box on occasion, and it can be challenging to remove the odors once they set in. Enzyme cleaners work well to remove smells by destroying the organic material that creates them. However, with so many different enzyme cleaners available, it can be challenging to find a brand that is non-toxic and effective at removing scents. We picked out several different kinds to focus on in these reviews, so you can see the difference between them. Keep reading as we look at product size, ingredients, effectiveness, and other factors to help you make an educated purchase.

A Quick Look at the Winners in 2025

Rating	Image	Product	Details
Best Overall		Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray	Gets the toughest jobs done Dissolves stains and eliminates odors Works on other scents like feces and vomit	CHECK PRICE
		PetSafe Wee Care Enzyme Cleaner	Safe to use around children and pets Multi-surface cleaner Eco-friendly	CHECK PRICE
		R&R Stain & Odor Eliminator	Safe to use around children and pets Multi-surface cleaner Freshens fabric	CHECK PRICE
		MisterMax Anti-Icky-Poo	Non-toxic Multi-surface cleaner Available in multiple sizes	CHECK PRICE
		Nature’s Miracle Stain Remover	Odo-locking technology Eliminates deep set-in odors No rinsing	CHECK PRICE

The 8 Best Cat Urine, Odor & Stain Removers

1. Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray — Best Overall

Hepper’s Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray is the best overall cat urine, odor & stain remover. This is an extremely effective and eco-conscious product that works to bind, lift, and remove even the most offensive urine smells. The bio-enzymatic formula isn’t just for cat urine either. You can also use it on drool, vomit, feces, and other substances.

This spray is simple to use. There’s no need to mix it with water. You just shake the bottle and spray it on the soiled area. The bio-enzymes will get to work right away to penetrate the area to both dissolve the stain and remove the odor at its source.

This cleaning spray is tough on stains and odors but won’t harm the surfaces in your home. It has been tested on carpets, flooring, fabrics, and furniture. Of course, you’ll want to perform a colorfastness test to be sure, but we love how versatile this formula is.

Another attractive feature of this spray is its neutral scent. Other odor eliminators on the market claim to remove odors at the source but instead just mask them with overpowering scents in their formulas. This spray, however, is void of any chemical fragrances, so when the urine smell is gone, you know it’s gone for good and not just hiding behind fragrance.

At PangoVet, we’ve admired Hepper for many years and decided to take a controlling ownership interest so we an benefit from the outstanding designs of this cool cat company!

2. PetSafe Pet Loo Wee Care Enzyme Cleaner

PetSafe Pet Loo Wee Care Enzyme Cleaner is the best cat urine, odor & stain remover for the money. It’s safe to use around children and other pets and is also safe for the environment. It works on multiple surfaces and contains no fragrance, so it’s perfect for people with sensitivities.

While PetSafe Pet Loo Wee Care Enzyme Cleaner works well, the small bottle runs out quickly.

3. Rocco & Roxie Supply Co. Professional Strength Pet Stain & Odor Eliminator

Rocco & Roxie Supply Co. Professional Strength Pet Stain & Odor Eliminator is a great premium product. It is a non-toxic cleaner that is safe to use around children and pets, and it has a nice odor that will leave your room smelling better. You can use it on multiple surfaces like fabrics, carpet, and furniture, and it’s easy to apply using the handy spray bottle.

The only negative things about Rocco & Roxie’s Stain & Odor Eliminator are that it doesn’t prevent cats from returning to the same place that you already cleaned and that the container is flimsy and tends to leak.

4. MisterMax Anti-Icky-Poo

MisterMax Anti-Icky-Poo is a great carpet cleaner for cat urine. This brand is available in many sizes, up to 1 gallon, and you can purchase it scented or unscented. It’s non-toxic and safe to use around children and pets, and you can use it on all surfaces. We found it especially useful on carpet because you can treat a large area.

While enzymes often require more than one treatment to eliminate everything, MisterMax Anti-Icky-Poo takes more applications to get rid of cat urine odor than what is typical.

5. Nature’s Miracle Hard Floor Stain & Odor Remover

Nature’s Miracle Hard Floor Stain & Odor Remover is a great enzymatic urine remover. We found that its odor-locking technology does an excellent job of getting rid of urine odors and has a special formula that works well on hard surfaces like concrete, brick, and tile, which is where other brands can struggle. The convenient spray bottle makes it easy to apply, and there is no need for rinsing.

The downside to Nature’s Miracle is that it contains a fragrance that many people don’t like. Also, while it does an excellent job of cleaning, some cats still return to the same spot to urinate again.

6. Simple Solution Pet Stain & Odor Remover With Pro-Bacteria & Enzyme Formula

Simple Solution Pet Stain & Odor Remover with Pro-Bacteria & Enzyme Formula is a decent cat urine and odor remover. It uses bacteria and enzymes to help destroy organic material and odors. It’s non-toxic and safe to use around children and pets. It has a special formula that works on multiple surfaces, including carpets, upholstery, bedding, and clothing.

The downside to Simple Solution Pet Stain & Odor is that it can take more than one application to remove the urine smell.

7. Nature’s Miracle Cat Urine Destroyer Plus Enzymatic Formula Stain Remover

Nature’s Miracle Cat Urine Destroyer Plus Enzymatic Formula Stain Remover is a great option for removing cat urine from carpets, hardwood, and even concrete. It comes in a large 1-gallon container, so you won’t run out in the middle of a job. It can remove deep-set stains and starts to work almost immediately while remaining safe to use around pets. Many people notice a difference just a few minutes after applying it.

The biggest downside to Nature’s Miracle Urine Destroyer is that it leaves a powerful smell that fills the room. It also lingers for several days, and some people might not like it. It works well, but due to the fragrance, you may only want to use it for big accidents.

8. Simple Solution Yard Odor Away

Simple Solution Yard Odor Away is the best urine remover for yards. It has a easy-to-use design that enables you to connect the container directly to your garden hose for the perfect mix. Each 32-ounce container can control odors over 25,000 square feet, more than enough for most homes. You can also use it on other surfaces like your porch, deck, sidewalks, and lawn furniture.

The downside to Simple Solution is that it contains mild detergents that can irritate the eyes, so we can’t recommend using it around pets or children. Since the container only connects to the garden hose, it’s strictly for outdoor use.

Buyer’s Guide: How to Select the Best Cat Urine, Odor & Stain Removers

What Are Enzyme Cleaners?

Enzymes are helpful bacteria that consume starch, oil, fat, protein, and other organic matter. While not all stains contain these elements, many of them do, and enzyme cleaners can help break them down, removing stains that would not be possible with traditional detergents. The slow breakdown of organic material is the source of many foul odors found in the home, and enzyme cleaners can help remove them.

What Can You Clean With Enzyme Cleaners?

Enzyme cleaners work perfectly for elimeinating urine, feces, vomit, blood, and anything else that comes from a living thing. It also works well to get rid of food stains and sometimes even the most difficult stains, like wine and blood. Enzyme cleaners also remove grease and oil, and many restaurants use them in their floor cleaners.

Is There a Downside to Enzyme Cleaners?

Eats Away at Certain Surfaces

The downside to enzyme cleaners is that they can eat away at certain surfaces if used too frequently. For instance, restaurants that use enzymes daily will notice that they can eat away at the grout between tiles, so it might not be a great choice for a floor with many small tiles. However, the process is extremely slow and only a concern if you are applying the enzymes several times a day for a long period.

Works Slowly

Most people expect to apply a product, rub it around a little, wipe it up, and have a clean surface, but that isn’t how enzymes work. Enzymes are living bacteria that spend their lives snacking on your stain. It takes time for them to eat it, and they may die before they finish because they have relatively short lifespans.

With enzymes, you apply them and keep checking back every few hours. The stain should start to fade, and you will need to reapply the emzmes every 24 hours until the stain is gone.

What Is the Benefit of Enzyme Cleaners?

Many stains can penetrate fabric and become locked, unable to be dislodged by traditional detergents, which frequently contain chemicals that can be harmful to your pet or yourself. Enzymes, however, are microscopic living bacteria that will eat the stain before dying. These bacteria are not harmful to people or pets, and they have short lifespans. They don’t create any odor or leave any residue behind that you need to rinse.

What Makes One Brand Better Than Another?

The primary thing that makes one brand better than another is the concentration of enzymes in the bottle. As the enzymes eat, they die, so if there are only a few, you will need to reapply it several times before your stain comes out. Unfortunately, there is no way to tell how concentrated most brands are, so you will need to resort to trial and error and customer reviews. Also, since many brands have limited ingredients, you can often guess the concentration based on cost.

Our Best Cat Urine, Odor & Stain Removers Selection Process

The cat urine, odor & stain remover we reviewed in this article were chosen by PangoVet’s writers and editors, in collaboration with our experienced veterinary team, based on personal experience with the product, knowledge and expertise about the pet’s care needs, brand reputation, and reviews across multiple retail outlets from other customers that have purchased and used the product. The combination of these factors allows us to gather a wide range of information to help you choose only the best cat urine, odor & stain remover and ensure you have the most accurate information about these products to promote proper care, health, and well-being of your beloved pets.

Why Trust PangoVet?

PangoVet’s licensed and experienced veterinarians have a knowledge base that extends to all kinds of pets—furry, scaly, and feathered—and want only the best for pets of all shapes and sizes. We also have experienced writers and editors who are pet owners with a variety of different pets, and we love our pets as much as you do. We recognize pets as part of our family. We make sure to only choose products from reputable brands highly rated by customers as well as products that we have personal experience with, to ensure that every cat urine, odor & stain remover featured in this review is high-quality and safe for your pets.

Final Thoughts

When choosing your next enzyme cleaner among these reviews, we highly recommend our pick as the best overall. Hepper Advanced Bio-Enzyme Pet Stain & Odor Eliminator Spray provides you with a highly versatile enzyme cleaner. The no-mix solution is more than suitable for most pet owners who have new or set-in accidents that require immediate clean-up. If your pet rarely has an accident and you are looking for something small for a single accident, we recommend the PetSafe Pet Loo Wee Care Enzyme Cleaner that comes in a small eco-friendly package and should eliminate your stain or odor without breaking the bank.

You might also be interested in: 

• Natural & Safe Home Remedies to Keep Cats Away
• How to Get Cat Pee Smell & Stains Out of a Couch
• 10 Best Cat Deodorizing Sprays- Reviews & Top Picks

Featured Image Credit: cunaplus, Shutterstock